![]() ![]() Among the discomforts, post-burn pruritus is a very common and distressing problem affecting individuals afflicted by a burn injury. There are many sensory discomforts including prickling, burning sensation, numbness, and stinging that occur in the post-burn state. Its risk factor appears to be higher in women, with larger burns, with more surgery, and with limb and facial burns The prevalence of pruritus tends to decrease with time, but, in some cases, it has persisted for more than a few years and the prevalence rate has reached 40% even after 12 years. The onset of the pruritus may occur within a few days after burn and the prevalence of pruritus after burn is 80–100%, according to reports. Post-burn pruritus is the pruritus that occurs during the wound healing process after a burn. In this review, we summarized the interaction and mechanism of keratinocytes, immune cells, and nerve fibers related to post-burn pruritus. An effective treatment for post-burn pruritus will also be effective in other neuropathic and intractable itching. The second one is the intact nociceptor hypothesis. The first one is peripheral sensitization. There are two mechanisms underlying post-burn neuropathic pruritus. When keratinocytes are activated by an itch-inducing substance, they secrete a variety of inflammatory substances that increase the susceptibility of the itch receptor. During wound healing, various neuropeptides secreted from the nerves of the skin control epidermal and vascular proliferation and connective tissue cells. Clinically, post-burn pruritus tends to be intractable to conventional treatment but rather responds to neuroleptic agents, such as gabapentin and pregabalin. The precise mechanism of post-burn pruritus has not been elucidated, but it appears to have pruritogenic and neuropathic aspects. Many potential treatments are available for pruritus but there is no consensus of the best single treatment yet. The post-burn pruritus is a common and serious complication of burn injury, which severely lowers the quality of life of the patient. Post-burn pruritus is the pruritus that occurs after burn during the rehabilitation and healing process of burn wounds. ![]()
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